In 2010, she made her debut as an actress in Instrucciones para mi funeral, an independent film made by Sebastián Radic as a graduation project.
Her first film was Una rosa de Francia, starring with Alex Gonzalez, at the age of 16.
In 2014, de Armas moved to Los Angeles.
In 2012, with one commercial feature movie to her name and three more then-about to be released Que pena tu familia, Aftershock, and The Green Inferno, Lorenza moved to Los Angeles, when she soon secured small roles in Hemlock Grove and I Am Victor.