Nixon was nominated as the gubernatorial candidate for the ; the party threw its support to Cuomo after Nixon lost in the Democratic primary.
She landed her first major supporting role in a movie as an intelligent teenager who aids her boyfriend in building a nuclear bomb in 's 1986.
Nixon filed a petition with 65,000 signatures, more than four times the 15,000 required, to force a primary election.
Nixon, and at the premiere of , 2009 The immense popularity of the series led Nixon to enjoy her first leading role in a feature, playing a video artist who falls in love, despite her best efforts to avoid commitment, with a bisexual actor who just happens to be dating a man her best friend in 2000 , as well as starring opposite in the holiday television movie Papa's Angels 2000.